In the position that defines the Italian Game vs Two Knights Defense the Engine move is for white to go for the knight attack, but in the position that has perfect mirror color symmetry to this position the engine move is to move a pawn despite the fact that each position can be transformed to the other position by reversing both the dimensions and the colors. Also the evaluation for the mirror color position is different from the opposite of the evaluation of the original position.
In this game I played for instance the knight attack was labeled an inaccuracy despite the fact that it is the engine move in the Italian Game vs Two Knights Defense, that the position on move 4 with black to play is mirror color symmetric to.